Molecular Formula | C47H74N16O10 |
Molar Mass | 1023.19 |
Storage Condition | −20°C |
In vitro study | GRGDS and Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide: WQPPRARI) micropatterns increase the endothelialisation of prosthetic materials in vitro. Fibronectin Adhesion-promoting Peptide also enhances haptotactic cell migration. The anti-apoptotic effects of fibronectin require the presence of the WQPPRARI sequence, which may be due to synergistic survival signals mediated by this sequence and by the RGD motif. RDGS and Fibronectin Adhesion-promoting Peptide promote cell adhesion through different activation pathways that induce different forms of adhesion which can be highlighted through the analysis of focal and fibrillar contacts. |
WGK Germany | 3 |
biological activity | Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is a kind of Heparin-Binding amino acid sequence, this sequence is present in the heparin binding domain at the C- terminus of fibronectin. Fibronectin Adhesion-promoting Peptide promotes the assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes endothelial cell Adhesion, diffusion and migration by reacting with the heparin-binding region of cells. |